Wegener's Granulomatosis

Disorder	Vasculitis	Epidemiology/Etiology	Clinical/Laboratory Findings
Wegener's granulomatosis	Necrotizing medium-sized and small vessel vasculitis involving upper respiratory tract, lung, renal vessels	Childhood to middle age	Necrotizing vasculitis in upper respiratory tract (nasopharynx, sinuses, trachea), lower respiratory tract (pulmonary vessels; infarction, pneumonia), kidneys (crescentic glomerulonephritis)
			Necrotizing granulomas in upper respiratory tract (saddle nose deformity), lungs c-ANCA antibodies (>90% of cases) Treatment: corticosteroids, cyclophosphamide

A 63-year-old man with pulmonary Wegener's granulomatosis. A chest radiograph shows multiple pulmonary masses, some of which are cavitating (arrows). Source BJR