Steroid Synthesis

Pulsatile GnRH

Men Syndromes

Multiple Endocrine Neoplasia Syndromes

•MEN 2A→ Mutation of germline RET ( neural crest cells)

Aspirin Intoxication

Aspirin poisoning will produce respiratory alkalosis initially then will produce metabolic acidosis.

Others producing Metabolic acidosis are:

Increased anion Gap (MUD PILES) M- Methanol U- Uremia D- DKA P- Paraldehyde or phenformin I- Iron tablets or INH L- Lactic Acidosis E- Ethylene glycol S- Salicilates

Normal anion Gap Diarrhea Renal Tubular Acidosis (alkaline urine ph < 5.5) Hyperchloreima

Insulin Release in Pancreatic β Cell

DO NOT GIVE THIAZIDES TO HYPERGLYCEMIC, HYPERLIPIDEMIC, & HYPERURICEMIC PATIENS
Remember that normally insulin will inhibit HSL (Hormone Sensitive Lipase) required for the breakdown of stored TG in adipose tissue. Since thiazides stop the production of ATP on the pancreatic β cell, preventing the realease of insulin required for keeping TG inside of adipose tissue, this drugs are not given to hyperlipidemic patients.

PTH DISORDERS & LEUKEMIAS AGE BRACKETS