Clinical and laboratory Findings in Vitamin B12 and Folate deficiencies

Clinical and laboratory Findings in Vitamin B12 and Folate deficiencies

LABORATORY / CLINICAL FINDING	PERNICIOUS ANEMIA	OTHER Vit B12 DEFICIENCIES	FOLATE DEFICIENCY
Achlorhydria	Present	Absent	Absent
Autoantibodies	Present	Absent	Absent
Chronic athrophic gastritis	Present	Absent	Absent
Gastric carcinoma risk	↑	None	None
Hypersegmented neutrophils	Present	Present	Present
Mean corpuscular volume	↑	↑	↑
Neurologic disease	Present	Present	None
Pancytopenia	Present	Present	Present
Plasma homocysteine	↑	↑	↑
Serum gastrin level	↑	Normal	Normal
Urine methylmalonic acid	↑	↑	Normal

Viruses

Lysosomal storage diseases