Primary Billiary Cirrhosis

Primary biliar Cirrhosis

Question

Triad: Confusion, Ataxia Ophthalmoplegia

Seen in:

Enzyme deficiencies

DISEASE Phenylketonuria Alkaptonuria Maple Syrup Urine Disease Homocysteinuria

ENZYME DEFICIENT Phenylalanine Hydroxylase (Cofactor: Tetrahydrobiopterin) Homogentisate Oxidase Branched -Chain Ketoacid DHase (=α-Ketoacid DHase)(TLCFN) Cystathionine Synthase (B6) Homocysteine Methyl Trasferase Methyl THF

Tx/SUPLEMENT Tyrosine Thiamine Cisteine

AVOID Phenylalanine, Aspartate Phenylalanine, Tyrosine Leucine Valine Isoleucine

Neurotransmitter changes

Anxiety:	↑NE,  ↓GABA,  ↓Serotonin (5-HT)
Depression:	↓NE,  ↓Serotonin (5-HT), ↓Dopamine
Alzheimer's dementia:	↓ Ach
Huntington's disease:	↓GABA, ↓Ach
Schizophrenia:	↑Dopamine.
Parkinson's disease:	↓Dopamine,  ↑Ach, ↑Serotonin (5-HT)

Immunodeficiencies

Apoyemos a Sisi y Tzuhsi

GANADORAS DEL CONCURSO "HOLIDAY TREAT CONTESTANTS: THE CUTEST PET" CON UN 76.97% DE LOS VOTOS!!!

 Gracias por votar por Sisi y Tzuhsi en el concurso the cutest pet 2011

Gram + Algorithm

Source FA (adapted)

No me doy por vencido en la voz de su autora CLAUDIA BRANT

Cyanide Poisoning