Monday, October 24, 2011

Cytocrome P450


INDUCERS
INHIBITORS
Effect on drugs
Decreased (fail to respond)
Increased (risk of toxicity)
Anticonvulsivants
Barbiturates (Phenobarbital)
Phenytoin
Carbamazepine
Ethosuximide
Valproic Acid
Antibiotics
Rifampin
Chloramphenicol
Quinolones (Ciprofloxacin)
Macrolides (Erythromycin)
Sulfonamides (TMT SMX)
Isoniazid (INH)
Antifungals
Griseofulvin
Ketoconazole
Fluconazole
Alcohol
Chronic alcoholism
Acute alcoholism
Fruits/ Plants
St. John's Wort
Grapefruit

Antiarrythmics
Quinidine

Sterols
Glucocorticois
Antiulcerous

Cimetidine
Omeprazole
Antivirals

Ritonavir (HIV protease inhs)
Antitumoral

Cyclosporin

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