Raynaud's Disease / Phenomenon

Disorder	Vasculitis	Epidemiology/Etiology	Clinical/Laboratory Findings
Raynaud's disease	Medium-sized vessel vasculitis involving digital vessels in fingers and toes	Young women Exaggerated vasomotor response to cold or stress	Paroxysmal digital color changes (white-blue-red sequence) Ulceration and gangrene in chronic cases
Raynaud's phenomenon	Medium-sized vessel vasculitis involving digital vessels in fingers and toes	Adult men and women Secondary to other diseases (e.g., systemic sclerosis, CREST syndrome)	Systemic sclerosis and CREST syndrome: digital vasculitis with vessel fibrosis, dystrophic calcification, ulceration, gangrene